Enzymatic Synthesis of Useful Alkyl .BETA.-Glucosides.

Palladium(0)-catalyzed synthesis of cyclic glucosides.

A highly regio- and stereo-selective synthesis of cyclic β-D-glucosides 3 via Pd(0)-catalyzed coupling cyclization of allenyl β-D-glucoside 1 and organic iodides in 20-38% yields is reported. After the deacetylation of 3, we obtained cyclic β-D-glucoses 4 in 90-97% yields, which may have SGLT2 inhibition activities.

Enzymatic diastereo- and enantioselective synthesis of α-alkyl-α,β-dihydroxyketones.

An enzymatic strategy for the preparation of optically pure α-alkyl-α,β-dihydroxyketones is reported. Homo- and cross-coupling reactions of α-diketones catalyzed by acetylacetoin synthase (AAS) produce a set of α-alkyl-α-hydroxy-β-diketones (30-60%, ee 67-90%), which in turn are reduced regio-, diastereo-, and enantioselectively to the corresponding chiral α-alkyl-α,β-dihydroxyketones (60-70%, ...

Enzymatic Synthesis and Hydrolysis of Linear Alkyl and Steryl Hydroxycinnamic Acid Esters

Effect of alkyl group substituents on the thermal and enzymatic degradation of poly (n-alkyl acrylates)

Effect of alkyl group substituents on the thermal and enzymatic degradation of poly (n-alkyl acrylates) J. P. Mahalik and Giridhar Madras∗ Department of Chemical Engineering, Indian Institute of Science, Bangalore-12 Abstract The effect of alkyl group substituents on the thermal degradation kinetics of poly (n-alkyl acrylate) was investigated in pyrolysis and in solution. The activation energie...

Enzymatic and chemo-enzymatic synthesis of carbohydrates

Carbohydrate-mediated biochemical recognition processes are potential targets for drug development. The synthesis of complex carbohydrates and related structures, however, has been a difficult task, especially from practical point of view. New solutionand solidphase methods based on enzymatic and a combined enzymatic and chemical procedure have recently been developed for the practical synthesi...